Classes are unavoidable in JavaScript if you care about performance. Recreating redundant functions inside a closure in performance critical code is a sure way to have slow apps.
Creating an object and creating a closure both need to allocate memory in the VM, but the closure doesn't need to expose its internals the way an object does and therefore can be further optimized by the runtime.
If you need to write performance critical JavaScript, then allocating new objects will be just as slow as creating new closures. In either cases you should allocate them ahead of time and then closures are still the clear winner.
> Creating an object and creating a closure both need to allocate memory in the VM, but the closure doesn't need to expose its internals the way an object does and therefore can be further optimized by the runtime.
Actually... creating an object instance via a constructor lets the runtime use an internal class, which improves performance (as long as you don't modify its properties post-construction). This is a well-known aspect of V8 performance.
Even with an internal class you're still doing lookups for properties. A closure can instead use local variables which are accessed by index. Why do you think its good practice to pull properties out of objects and into local variables before a tight loop?