Evolution is not operating at the speed necessary on population to the change of circumstances we have generated over the last 15,000 years. Especially in the modern world, where it is hardly clear that the reproduction rates of the people happiest in it are higher. Probably the opposite is true.

So yes, it is totally possible that we have been fucking it up with respect to our biology for thousands of years. In fact there is a pretty substantial body of work and evidence that hunter-gatherers are happier than than people living the post agricultural/industrial lifestyle.