If you want to stick with a language you know, ASP.net MVC and Django are both great full stack frameworks for getting complex stuff done quickly and well.
If you want to go a bit more of a futureproof route, focus on learning something like backbone or ember, and treat your server as an api. In that case, what framework you choose doesn't matter so much, as long as it provides good json serialization and easy data access.
If you want to go a bit more of a futureproof route, focus on learning something like backbone or ember, and treat your server as an api. In that case, what framework you choose doesn't matter so much, as long as it provides good json serialization and easy data access.