You do lose out on a lot of human bias in the research process, but you also create blind errors that are hard to validate.
I know in my work there is plenty of times I run analysis and go back and manually check some entries as a sanity check - pros and cons here!
Here's a talk on differential privacy applied to the overfitting problem [1]
[0] http://andyljones.tumblr.com/post/127547085623/holdout-reuse
[1] https://www.youtube.com/watch?v=9mqXjdnZA18