That is when you see the whole tool chain, OSX, Xcode, Compiler all optimized for Ryzen in WWDC. I hope.
I honestly dont think any consumer will stop buying Mac just because Intel isn't inside the Mac. And it will save Apple at least $200 BOM per Mac, making final Mac Selling price around ~$250 less. Slightly more affordable. Or more likely, staying within the same pricing and give you double the SSD storage.
You can't even run the stock kernel on AMD chips. How much QA and other work Apple would have to do, I have no idea.